President Thomas Jefferson gave Meriwether Lewis detailed instructions for the expedition. While its primary mission was to explore waterways for a route to the Pacific Ocean, commerce with inhabitants of the region was a major goal. Jefferson specified the kinds of information Lewis should obtain about any American Indian nations he might encounter.
The commerce which may be carried on with the people inhabiting the line you will pursue, renders a knolege [sic] of those people important. You will therefore endeavor to make yourself acquainted . . . with the names of the nations & their numbers; . . . their possessions; their relations . . . ; language, traditions, monuments; . . . occupations . . . ; food, clothing, & domestic accommodations; . . . diseases . . . , & . . . remedies . . . ; . . . their laws, customs . . . ; and articles of commerce they may need or furnish & to what extent.
Manuscript Division, Library of Congress