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The Kansas-Nebraska Act was a major step leading to the Civil War. It overthrew the Missouri Compromise and gave the residents of new territories the power to decide whether to allow slavery. It more firmly wed slavery with states’ rights and created uncertainty about the extent of slavery in the western territories.
…it being the true intent and meaning of this act not to legislate slavery into any Territory or State, nor to exclude it there from, but to leave the people thereof perfectly free to form and regulate their domestic institutions in their own way…
Records of the U.S. Senate, National Archives and Records Administration, Washington, D.C.