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Based on the deep and resonant isolationist sentiment among many Americans, some members of Congress opposed the League of Nations because they feared U.S. entanglement in international affairs. Senator Henry Cabot Lodge, Chairman of the Senate Foreign Relations Committee, prepared a series of 'reservations' or modifications to the Treaty of Versailles in an effort to reflect these concerns.
…the United States declines to assume…any obligation to preserve the territorial integrity or political independence of any other country…
Records of the U.S. Senate, National Archives and Records Administration, Washington, D.C.